Easily fabricated and recyclable Pd&Cu@Al catalyst for gram-scale phosphine-free Heck reactions with high TON

作     者：Dongliang Zhang Zheng Wei Lei Yu 

作者机构：Institute of PesticideSchool of Horticulture and Plant ProtectionYangzhou University School of Chemistry and Chemical EngineeringYangzhou University 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2017年第62卷第19期

页      面：1325-1330页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Natural Science Foundation of China (21202141) Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions the Young Science and Technology Talent Support Project of Jiangsu Province (Lei Yu) the High Level Talent Support Project of Yangzhou University (Topnotch Talent, Lei Yu) the Open Project Program of Jiangsu Key Laboratory of Zoonosis (R1509) the Testing Centre of Yangzhou University 

主　　题：Heck反应 新型催化剂 铝箔 金属纳米粒子 回收 制造 膦 铜 

摘      要：A unique Pd&Cu@Al catalyst was easily fabricated just by immersing commercial aluminum foil in a mixed xylene solution of PdCl_2 and CuCl_2. The catalyst fabrication process led to aluminum oxide coatings in situ, which supported the metal nanoparticles and enhanced their catalytic activities for the phosphine-free Heck reaction of aryl halides and styrenes with high turnover number(TON) up to 3.9×10~5. The reaction can be scaled up to at least 100 mmol and has been applied in modification of drug Lapatinib s intermediate with low metal residue. This novel catalyst is of good application potential in industrial production because it was extremely easy to be recycled, in regardless of the generation of the insoluble impurities or tars during the reaction processes.