Trends in Antimicrobial Resistance against Enterobacteriaceae Strains Isolated from Blood： A 10-year Epidemiological Study in China's Mainland （2004-2014）

作     者：Xiang-Jun Liu Yuan Lyu Yun Li Feng Xue Jian Liu Liu Xiang-Jun;Lyu Yuan;Li Yun;Xue Feng;Liu Jian

作者机构：Institute of Clinical Pharmacology Peking University First Hospital Beijing 100034 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2017年第130卷第17期

页      面：2050-2055页

核心收录：

学科分类：090603[农学-临床兽医学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 100403[医学-营养与食品卫生学] 10[医学] 

基　　金：Hanzhong Center Hospital Institute of Clinical Pharmacology, Peking University First Hospital Jinan Central Hospital Kunming First People’s Hospital (Kunming), Affiliated Hospital of Guiyang Medical College Lanzhou University Second Hospital (Lanzhou), The First Teaching Hospital of Xinjiang Medical University Xijing Hospital Zhejiang University (Hangzhou), Guangzhou Women and Children’s Medical Center Zhongshan Hospital Fudan University (Shanghai), Sir Run Run Shaw Hospital School of Medicine Third Military Medical University, TMMU Nanjing Medical University, NMU Fourth Military Medical University, FMMU Tianjin Medical University, TMU Southwest Hospital Xiangya Hospital, Central South University Hebei Medical University, HEBMU Renmin Hospital of Wuhan University, RHWU Beijing Hospital 

主　　题：Antimicrobial Resistance Trend Blood Sample Enterobacteriaceae In vitro Activity Susceptibility 

摘      要：Background：Antimicrobial resistance is a serious problem that compromises the empirical treatment of infections,resulting in a lack of effective antibiotics and high medical ***,we aimed to monitor the trends in antimicrobial resistance among Enterobacteriaceae isolated from blood samples in China s ***：A total of 2240 Enterobacteriaceae isolates from blood were collected from hospitalized patients at 19 tertiary hospitals between October 2004 and June *** minimum inhibitory concentrations of all isolates were determined using the agar dilution method according to the Clinical and Laboratory Standards Institute 2016 ***：The most commonly isolated bacteria were Escherichia coli,compromising 47.0% （1053/2240） of the total isolates,followed byKlebsiella spp.（26.3%）,Sahnonella spp.（10.4%）,and Enterobacter spp.（9.2%）.The detection rates of extended-spectrum β-lactamases （ESBLs） among *** were 68.9% （2004-2005）,73.2% （2007-2008）,67.9% （2009-2010）,72.6% （2011-2012）,and 58.4% （2013-2014）,whereas those in ESBL-producing Klebsiellapneumoniae were slightly decreased （75.9%,50.0%,41.4%,40.2%,and 43.0%,respectively）.Carbapenems were the most potent agents against the Enterobacteriaceae isolates,followed by moxalactam,tigecycline,and ***,there was a decrease in the susceptibility rates for carbapenems in all species,particularly *** （decreased by 10.6% for imipenem） and Enterobacter aerogenes （decreased by 2 l.1% for imipenem）.Reviving antibiotics （tigecycline and polymyxins） showed good in vitro activity against ***：The activity of antibiotics against Enterobacteriaceae isolated from blood was decreased *** proportions of ESBL-producing isolates were identified among *** and Klebsiella ***-resistant isolates have become a major challenge in the treatment of infections.