Amplified ultraviolet detection of natural DNA based on Mo_6S_(9-x)I_x nanowires

作     者：Hong Lin Mei-Xian Li Fei Liu Dragan Mihailovi 

作者机构：Department of ChemistryCollege of Resources and EnvironmentYuxi Normal University College of Chemistry and Molecular EngineeringPeking University Jozef Stefan InstituteJamova 39SI-1000 Ljubljana 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2014年第25卷第4期

页      面：645-648页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 080202[工学-机械电子工程] 070302[理学-分析化学] 0703[理学-化学] 0802[工学-机械工程] 

基　　金：supported by the National Natural Science Foundation of China(No.20875005) 

主　　题：dsDNA MoSI nanowires Ultraviolet spectrophotometry Detection 

摘      要：We demonstrate that Mo6S9-xIx nanowires （MoSI NWs） can serve as an excellent signal-intensifying nanomaterial for highly sensitive and label-free detection of DNA by ultraviolet （UV） spectrophotometry. The DNA extinction at 260 nm was greatly enhanced after addition of MoSI NWs solute, and the extinction value was linear with DNA concentration in the range of 0.0289-11.68 μg/mL with the real determination limit of 28.9 ng/mL. The association of DNA with the nanowires was characterized by transmission electronmicroscopy and circular dichroic spectroscopy. The results illustrate that the UV response amplification of DNA in the presence of MoSI NWs is attributed to the greater DNA coverage on the MoSI NW surface and the conformational transformation of DNA due to interaction of DNA with MoSI NWs. MoSI NWs are a promising nano-structured material for developing ultrasensitive sensors for detection of DNA.