Caecal pH is a biomarker of excessive colonic fermentation

作     者：Adam D Farmer Sahar D Mohammed George E Dukes S Mark Scott Anthony R Hobson 

作者机构：Centre for Digestive DiseasesBlizard Institute of Cell and Molecular ScienceWingate Institute of NeurogastroenterologyBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondon E1 2AJUnited Kingdom GlaxoSmithKline Research and Development Durham CountyNC 27709-3398United States Functional Gut ClinicLondon W1G 6NBUnited Kingdom 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第17期

页      面：5000-5007页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by A Grant from the SmartPill Corporation 

主　　题：Caecal pH Caecoparesis Bloating Colonic microbiota 

摘      要：AIM:To ascertain whether caecal pH is different in patients with irritable bowel syndrome(IBS),whose primary symptoms are bloating and distension,to healthy ***:Motility and pH data were reviewed from16 patients with RomeⅢdefined IBS and 16 healthy controls,who had undergone a wireless motility capsule(WMC)study using a standardized *** measures were anchored around known anatomical landmarks as identified by compartmental pH ***-minute epochs were used to quantify antral,duodenal,ileal,caecal and distal colonic *** maximum and minimum pH was measured either side of the ileo-caecal ***:No differences were seen in motility parameters,compartmental transit times or maximal ileal pH between the two *** pH was significantly lower in patients compared to controls(5.12±0.05vs 6.16±0.15,P0.0001).The ileal:caecalΔchange was greater in patients than controls(-2.63±0.08 vs-1.42±0.11,P0.0001).There was a significant correlation between caecal pH and right colonic contractility(r=0.54,P=0.002).CONCLUSION:Patients with bloating and distension have a lower caecal pH compared to *** measurement of caecal pH using the WMC provides a quantifiable biomarker of fermentation potentially identifying those patients that may preferentially benefit from antibiotic or dietary interventions.