Biased ligand bonds to make right calls—laboratory of signal transduction reveals molecular mechanism for functional selectivity of GPCR

作     者：WANG Jue Wang J

作者机构：Institute of Molecular Medicine Peking University 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第7期

页      面：957-958页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University Foundation of Polish Science National Institutes of Health, NIH National Institute on Aging, NIA National Natural Science Foundation of China, NSFC National Basic Research Program of China (973 Program) 

主　　题：G蛋白偶联受体 信号转导 功能选择 分子机制 配体 实验证据 分子医学 生物化学 

摘      要：In a recent study,Professor Rui-Ping Xiao and her research group at Institute of Molecular Medicine of Peking University has provided an essential experimental evidence to support the new paradigm of functional selectivity for G protein-coupled receptor(GPCR)signal transduction.The study was published online on May 15 in The Journal of Biological Chemistry[1].The GPCR superfamily,a class of membrane