Interleukin 4-induced neuroprotection and regulation of microglia activation as a therapeutic approach in the MPTP model of Parkinson's disease

作     者：Bjorn Spittau 

作者机构：Institute for Anatomy and Cell Biology Department of Molecular Embryology Faculty of Medicine University of Freiburg Institute of Anatomy University of Rostock 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2017年第12卷第9期

页      面：1433-1434页

核心收录：

学科分类：08[工学] 0905[农学-畜牧学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090501[农学-动物遗传育种与繁殖] 090102[农学-作物遗传育种] 

基　　金：supported by the Deutsche Forschungsgemeinschaft(DFG SP 1555/2-1) 

主　　题：T-CELLS NEURONS BRAIN CYTOKINE 

摘      要：Parkinson＇s disease （PD） has been described as one of the most common neurodegenerative diseases affecting up to 2% of the worldwide population over 60 years of age. The hallmarks of PD are progressive loss of midbrain dopaminergic （mDA） neurons and a decrease in striatal dopamine levels, which result in typ- ical clinical motor symptoms such as akinesia, resting tremor, rigidity, and gait impairments. Although the causes for PD are only partially understood and seem to be very heterogeneous, one of the common phenomenons observed in toxin-based an- imal models of PD as well as PD patients is a microglia-driven neuroinflammatory response,