Serum uric acid is a risk factor for large-artery atherosclerosis cerebral infarction

作     者：Jianjun Guo Qingyu Shen Jie Li Xiaoming Rong Ying Peng Yamei Tang 

作者机构：Department of Neurology Zengcheng People＇s Hospital Zengcheng 511300 Guangdong Province China Department of Neurology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou 510120 Guangdong Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第36期

页      面：2856-2859页

核心收录：

学科分类：090603[农学-临床兽医学] 0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0906[农学-兽医学] 

基　　金：the Natural Science Foundation of Guangdong Province, No. 10151130001000001, S2011010004708 the Science and Technology Projects of Guangdong Province, No. 2010Y1-C191 

主　　题：uric acid stroke large-artery atherosclerosis small-artery occlusion 

摘      要：Using the Trial of Org 10172 in Acute Stroke Treatment （TOAST） classification for acute ischemic stroke, 371 patients with either acute large-artery atherosclerosis or small-artery oc-clusion cerebral infarction were recruited to investigate the potential impact of elevated serum uric acid on cerebrovascular disorders. The results showed that patients who have suffered from large-artery atherosclerosis, relative to small-artery occlusion patients, were characterized by elevated serum uric acid but reduced high-density lipoprotein cholesterol and triglyceride levels. Logistic regression showed that elevated uric acid and lower triglyceride levels were the main risk factors for patients with large-artery atherosclerosis. The findings of this study suggest that hyperuricemia may be a risk factor for stroke.