Seeking the“mother of blood”from human pluripotent stem cells:Are we there yet?

作     者：Fei Li 

作者机构：The Editorial Office of Genes&DiseasesChongqing Medical UniversityChongqing400046China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2017年第4卷第3期

页      面：123-124页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

主　　题：Hemaotpoietic stem cells Human iPSC Lentiviral transduction Teratoma Transcription factors Xeno-transplantation 

摘      要：Induced pluripotent stem cells(iPSCs)hold great promise for the treatment of human diseases,including the failure of bone *** progress across the past three and half decades has brought us closer to making hematopoietic stem cells from iPSCs clinical solutions.A recent innovative two-step differentiation approach successfully generated transplantable HSCs from iPSC *** clinical translation,the long-term safety of these gene-altered HSCs must be determined.