On the Synthesis of Stereocalpin A： Partial Retraction/ Correction of Previous Results and Rationalization of the Hidden Difficulties

作     者：Zhiwei Zhao Yikang Wu Yan Li 

作者机构：Hubei Collaborative Innovation Center for Advaneed Organic Chemical Materials and Ministry-of-Education Key Laboratory for Synthesis and Application of Organic Functional Molecules Hubei University Wuhan Hubei 430062 China State Key Laboratory of Bioorganic and Natural Products' Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2017年第35卷第7期

页      面：1185-1194页

核心收录：

学科分类：07[理学] 08[工学] 070104[理学-应用数学] 0835[工学-软件工程] 0701[理学-数学] 081202[工学-计算机软件与理论] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

主　　题：peptide natural product aldol reaction cyclization condensation 

摘      要：In continuation/checking of a previous synthesis directed toward the literature structure of stereocalpin A it was found that the data for a substantial part of the intermediates reported before were incorrect. Some of the transfor- mations were not successfully reproduced and the failures were shown to be consequences of the presence of the N-Me and the particular location of the ester linkage. The origins of the ＂extra/minor＂ signals in the NMR for most of the intermediates, which tend to be mistaken as signs for the presence of impurity/isomers, are also discussed.