Enzymatic Regioselective Synthesis of Vinyl Lactose Ester and Its Chemical Polymerization

作     者：Qi WU Jian Yue FENG Chen Guo FENG De Shui LU Xian Fu LIN 

作者机构：Department of ChemistryZhejiang UniversityHangzhou 310027 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2002年第13卷第5期

页      面：416-419页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Regioselectivity vinyl ester lactose alkaline protease polymerization. 

摘      要：Transesterification reaction of lactose with divinyladipate in pyridine catalyzed by an alkaline protease from Bacillus subtilis at 50C for 3 days gave 6-O-vinyladipoyl-lactose (yield 35%). Poly(6-O-vinyladipoyl-lactose) with Mn = 21,200, Mw = 32,900, Mw/Mn = 1.56 could be obtained by chemical polymerization. Poly(vinyl alcohol) containing lactose branch was biodegradable. After 6 days in aqueous buffer (PH 7), this alkaline protease could degrade the polymer to an Mn of ca. 2100, Mw/Mn = 2.56.