氧化反应相关基因多态性与先兆子痫发病的风险

作     者：Kim Y.J. Park H.S. Park M.H. 李跃萍 

作者机构：Dept. of Obstetrics and GynecologyEwha Womans University 9111 MokDong Yangcheonku Seoul 151- 070 South Korea 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第7期

页      面：23-23页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：先兆子痫 氧化反应 基因多态性 过氧物酶 健康孕妇 纯合子 谷胱甘肽转移酶 无显著性差异 细胞色素氧化酶 遗传基因 

摘      要：Objective: The purpose of this study was to determine whether genetic variability in oxidative stress- related enzymes contributes to individual preeclampsia susceptibility differences. Study Design: Polymorphisms in the cytochrome P450 (CYP)1A1 (MspI), CYP1A1(Ile/Val), glutathione Stransferase (GST)M1, GSTT1, myeloperoxidase (MPO), and manganese superoxide dismutase (MnSOD) genes were evaluated by polymerase chain reaction (PCR) or PCR- restriction fragment length polymorphism (RFLP) in 214 healthy controls with an uncomplicated obstetric history, and in 121 preeclampsia patients. χ 2 analyses were used to statistically evaluate differences. Results: No significant differences in the CYP1A1(MspI) or CYP1A1(Ile/Val) genotypes were observed between the healthy controls and the preeclampsia patients (χ 2 = 1.43, P = 0.49 versus χ 2 = 1.54, P = 0.46). The GSTM1 homozygous null type and GSTT1 homozygous null type were no differences in the patients and controls (χ 2 = 0.01, P = 0.92 versus χ 2 = 0.31, P = 0.57), and no significant differences in the polymorphisms of the MPO and MnSOD genotypes were found between the patients and controls (χ 2 = 2.00, P = 0.37 versus χ 2 = 0.07, P = 0.96). Conclusion: Polymorphisms in the oxidative stress- related genes (CYP1A1, GSTM1, GSTT1, MPO, MnSOD) do not seem to be risk factors for preeclampsia.