Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy

作     者：C Ganesh Pai M Ganesh Kamath Mamatha V Shetty Annamma Kurien 

作者机构：Department of Gastroenterology and HepatologyKasturba Medical CollegeManipal University Department of PhysiologyMelaka Manipal Medical CollegeManipal University Department of PathologyMelaka Manipal Medical CollegeManipal University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第19期

页      面：3538-3545页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Drug therapy Endoscopy Exocrine insufficiency Pancreatic diabetes Pancreatic duct stents Quality of life Recurrent acute pancreatitis Surgery 

摘      要：AIM To assess the outcomes of drug therapy(DT)followed by pancreatic endotherapy for continuing painful episodes in recurrent acute *** DT comprised of pancreatic enzymes and antioxidants failing which,endotherapy(ET;pancreatic sphincterotomy and stent placement)was *** frequency of pain,its visual analogue score(VAS),quality of life(Qo L),serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and *** was defined as at least 50%reduction in the severity of pain to below a score of *** Of the thirty nine patients analysed,21(53.9%)responded to DT and 18(46.1%)underwent *** VAS for pain(7.0±2.0 vs 1.3±2.5,P0.001)and the number of days with pain per month decreased[1.0(1.0,2.0)vs 1.0(0.0,1.0),P0.001],and the Qo L scores[55.0(44.0,66.0)vs 38.0(32.00,51.00),P0.01]improved significantly during follow *** significant improvements were seen in patients in the subgroups of DT and ET except for Qo L in *** serum C-peptide(P=0.001)and FE(P0.001)levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on *** A standardised protocol of DT,followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis,enhanced Qo L and improved pancreatic function.