Study on the inclusion interaction of methylated-β-cyclodextrins with albendazole by spectrofluorimetry and its application
Study on the inclusion interaction of methylated-β-cyclodextrins with albendazole by spectrofluorimetry and its application作者机构:Analytical and Testing Center Shanxi Normal University Linfen 041004 China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2008年第19卷第8期
页 面:951-954页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金:the Natural Science Foundation of Shanxi(No.2007011027)
主 题:Methylated-β-cyclodextrins Albendazole Spectrofluorimetry
摘 要:The inclusion interaction between three types of methylated-β-cyclodextrins (Me-β-CDs) and albendazole (ABZ) was studied by spectrofluorimetry. The result showed that Me-β-CDs reacted with ABZ to form an inclusion complex, 1: 1 stoichiometry for Me- β-CDs-ABZ complex was established and its association constant have been determined from fluorescence data by Benesi- Hildebrand's method (double reciprocal plots). It was noted that 2,6-DM-β-CD exhibited stronger binding ability than other Me-β- CDs. Based on the significant enhancement of fluorescence intensity of inclusion complex, a simple and highly sensitive fluorimetric method is proposed for the determination of ABZ in the presence of 2,6-DM-β-CD. The proposed method was successfully applied to the determination of ABZ in tablets and human urine.