Recent advances in the identification of the host factors involved in dengue virus replication

作     者：Yi Wang 

作者机构：Department of Immunology Institute of Human Virology Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China Key Laboratory of Tropical Diseases Control (Sun Yat-sen University) Ministry of EducationGuangzhou 510080 China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2017年第32卷第1期

页      面：23-31页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (81371794) Guangdong Natural Science Foundation (2014A030311007) 

主　　题：dengue virus (DENV) host factors replication proteins miRNAs 

摘      要：Dengue virus(DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and *** researches have indicated that a variety of host factors, including cellular proteins and micro RNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings(from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.