Surface modification of nanozymes

作     者：Biwu Liu Juewen Liu 

作者机构：Department of Chemistry Waterloo Institute for Nanotechnology University of Waterloo Waterloo Ontario N2L 3G 1 Canada 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2017年第10卷第4期

页      面：1125-1148页

核心收录：

学科分类：07[理学] 

基　　金：the Liu lab at the University of Waterloo is from the Canadian Foundation for Innovation 加拿大自然科学与工程研究理事会(NSERC)项目 

主　　题：enzyme-mimics nanozymes adsorption peroxidases biosensors 

摘      要：Nanoparticles and proteins are similar in a number of aspects, and using nanoparticles to mimic the catalytic function of enzymes is an interesting yet challenging task. Impressive developments have been made over the past two decades on this front. The term nanozyme was coined to refer to nanoparticle- based enzyme mimics. To date, many different types of nanozymes have been reported to catalyze a broad range of reactions for chemical, analytical, and biomedical applications. Since chemical reactions happen mainly on the surface of nanozymes, an interesting aspect for investigation is surface modification. In this review, we summarize three types of nanozyme materials catalyzing various reactions with a focus on their surface chemistry. For metal oxides, cerium oxide and iron oxide are discussed as they are the most extensively studied. Then, gold nanoparticles and graphene oxide are reviewed to represent metallic and carbon nanomaterials, respectively. Types of modifications include ions, small molecules, and polymers mainly by physisorption, while in a few cases, covalent modifications were also employed. The functional aspect of such modification is to improve catalytic activity, substrate specificity, and stability. Future perspectives of this field are speculated at the end of this review.