Antimicrobial Susceptibility Testing and Molecular Characterization of Mycobacterium fortuitum Isolates in China

作     者：ZHENG Hui Wen PANG Yu HE Guang Xue SONG Yuan Yuan ZHAO Yan Lin 

作者机构：National institute for communicable disease control and prevention Chinese center for disease control and prevention Beijing 102206 China National Tuberculosis Reference Laboratory Chinese Center for Disease Control and Prevention Beijing 102206 China Science and Technology Department Chinese Center for Disease Control and Prevention Beijing 102206 China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2017年第30卷第5期

页      面：376-379页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：supported by a grant from the National Basic Research Program of China 2014CB744403 National Science and Technology Major Project 2014ZX100030002 

主　　题：Nontuberculosis Genotype Phenotype Susceptibility 

摘      要：We performed molecular identification of clinical isolates of Mycobacterium fortuitum（M. fortuitum） and conducted drug susceptibility testing to analyze the in vitro susceptibility of clinical M. fortuitum isolates and potential molecular mechanism conferring resistance to fluoroquinolone and macrolide drugs. The results showed that moxifloxacin had the highest in vitro activity against M. fortuitum, and most M. fortuitum isolates were resistant to clarithromycin and linezolid in China. The loss of genetic mutation in clarithromycin-and amikacin-resistant isolates indicates that some other intrinsic mechanism conferring clarithromycin and amikacin resistance plays an essential role in M. fortuitum infection.