Cytotoxic Effects of Biodegradation of Pure Mg and MAO-Mg on Tumor Cells of MG63 and KB

作     者：Qiang Wang1a Shi Jin Xiao Lin Yang Zhang Ling Ren Ke Yang 

作者机构：School of StomatologyChina Medical University Institute of Metal ResearchChinese Academy of Sciences 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2014年第30卷第5期

页      面：487-492页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：support of the National Natural Science Foundation of China(No.30970715 and No.2012CB619101) Chinese Academy of Sciences,Applied Research of Bioactive Bone Implanted Materials(No.KGCX2YW-207) 

主　　题：Magnesium ahoy Degradation Cytotoxic effect Tumor cell 

摘      要：Magnesium （Mg） based metals possess unique features of biodegradation that can be used for different purposes. In this study, two tumor cells, MG63 and KB, were cultured directly on a pure Mg with and without MAO coating to evaluate their cytotoxic effects on the tumor cells. It was found that both MG63 cells and KB cells adhered better on the surface of the coated Mg samples than those on the pure Mg samples. However, the survivals of two kinds of tumor cells were obviously inhibited on both Mg samples with and without coating, compared with that on the pure titanium. In addition, the survival of MG63 cells was more susceptive to the Mg degradation compared with the KB cells. Thus, the application of such effect should take account of that the degradation of Mg based metal may result in different cytotoxic effect on different cells.