Curative effect of Xuebijing injection on severe pulmonary contusion

作     者：Yi Chen Huasheng Tong Wang Zhang Xingqin Zhang Zhigguo Pan Junming Qiu Ruihuan Pan Lei Su 

作者机构：Department of Critical Care Medicine Taiping People's Hospital of Dongguan Key Laboratory of Tropical Trauma Care and Tissue Repair of Chinese People's Liberation Army Department of Critical Care Medicine General Hospital of Guangzhou Military Command Key Laboratory of Tropical Trauma Care and Tissue Repair of Chinese People's Liberation Army Rehabilitation Department Guangdong Province Traditional Chinese Medical Hospital 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2013年第33卷第6期

页      面：743-751页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Supported by grants from the National Natural Science Foundation of China(No.81101406)and(No.81071529) Project of Medical Research of PLA BWS12J108 

主　　题：Contusions Ventilator-induced lung in-jury Systemic inflammatory response syndrome Immunity HLA-DR antigens Procalcitonin Xuebi-jing injection 

摘      要：OBJECTIVE： To investigate the curative effects of Xuebijing （XBJ） injection, a Chinese patent medi- cine, on severe pulmonary contusion （PC）. METHODS： Sixty-three patients with PC were ran- domized to conventional therapy plus XBJ injec- tion （n=33） or conventional therapy alone （n=30）. Between groups differences in corticosteroid treat- ment, immune regulation therapy, hemofiltration, infusion volume, transfusion volume and antibiotic period were measured, as were intensive care unit（ICU）-free time, ventilation time, 28-day mortality rate and incidence of ventilation-associated pneu- monia （VAP）. Serum concentrations of procalcito- nin （PCT）, tumor necrosis factor-a （TNF-a）, interleu- kin （IL）-6, and 11_-10, white blood cell （WBC） counts and percentages of human leukocyte antigen DR/ CD14＋ （HLA-DR/CD14＋） peripheral blood mononu- clear cells were compared. Markers of ventilation were determined by blood gas analysis and ventila- tor parameters. RESULTS： WBC counts and serum concentrations of PCT, TNF-a, 11.-6 and IL-10 were reduced signifi- cantly more quickly, and CD14＋ percentage was in- creased significantly earlier, in the XBJ group than in the control group （P〈0.05 each）. The level of ven- tilation and oxygenation index were ameliorated earlier in the XBJ than in the control group （P〈 0.05）. XBJ treatment significantly reduced ICU-free time, ventilation time and incidence of VAP （P〈0.05 each）, but had no effect on 28-day mortality rate （P〉0.05）. CONCLUSION： XBJ treatment can shorten ICU-free and ventilation times and reduce the incidence of VAP, improving outcomes in patients with severe PC. XBJ may act by regulating inflammation and im- munity, alleviating systemic inflammatory response syndrome induced by trauma.