High serum interleukin-6 level is associated with increased risk of delirium in elderly patients after noncardiac surgery： a prospective cohort study
High serum interleukin-6 level is associated with increased risk of delirium in elderly patients after noncardiac surgery： a prospective cohort study作者机构：Department of Anesthesiology and Surgical Intensive Care PekingUniversity First Hospital Beijing 100034 China Departmen~ of~nesthesiology Civil Aviation General HospitalBeijing 100025 China Department of Anesthesiology Beijing Jishuitan Hospital Beijing100035 China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2013年第126卷第19期
页 面：3621-3627页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070602[理学-大气物理学与大气环境] 0706[理学-大气科学]
基 金：a grant from Peking University Clinical Research Program
主 题：elderly surgical procedures, operative interleukin-6 delirium postoperative complications
摘 要：Background The relationship between inflammation and delirium remains to be *** purposes of this study were to investigate the association between serum interleukin-6 levels and the occurrence of delirium in elderly patients after major noncardiac *** A total of 338 elderly patients （60 years of age and over） undergoing major noncardiac surgery were *** samples were obtained before anesthesia and in the first postoperative morning and serum interleukin-6 concentrations were *** was assessed twice daily by the confusion assessment method for the Intensive Care Unit during the first three postoperative *** analyses were performed to assess the relationship between the serum IL-6 level and the occurrence of postoperative *** Postoperative delirium occurred in 14.8% （50 of 338） of *** serum interleukin-6 levelsafter surgery were significantly associated with increased risk of the occurrence of postoperative delirium （hazard ratio 1.514,95% confidence interval 1.155-1.985,P=0.003）.Other independent predictors of delirium included increasing age,poor preoperative New York Heart Association classification,low preoperative Mini-Mental State Examination score,and high total postoperative Visual Analogue Scale pain *** who developed delirium had a prolonged hospital stay after *** Delirium is a frequent complication in elderly patients after noncardiac *** serum interleukin-6 level after surgery is associated with increased risk of the occurrence of postoperative delirium.
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