Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis

作     者：Liang Du Zhifeng Ning Fuxing Liu Hao Zhang 

作者机构：Cancer Research CenterShantou University Medical College Basic Medicine CollegeHubei University of Science and Technology Department of BiotherapyAffiliated Cancer Hospital of Shantou University Medical College 

出 版 物：《Chinese Journal of Cancer》 (Chinese Journal of Cancer)

年 卷 期：2017年第36卷第3期

页      面：139-149页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported in part by the National Natural Science Foundation of China(Nos.81071736,30973508,and 81572876) the Clinical Research Enhancement Initiative of Shantou University Medical College(Nos.201412 and 201421) the Collaborative and Creative Center,Molecular Diagnosis and Personalized Medicine,Shantou University,Guangdong Province,and the Department of Education,Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases(Nos.2015072,2015065,2015020,and 2015077) 

主　　题：Metastasis associated proteins Coregulator NuRD complex Master regulator 

摘      要：Worldwide,metastasis is the leading cause of more than 90%of cancer-related ***,no specific therapies effectively impede *** processes are controlled by complex regulatory networks and transcriptional *** metastasis-associated protein 3(MTA3)has been confirmed as a novel component of nucleosome remodeling and histone deacetylation(NuRD).Increasing evidence supports the theory that,in the recruitment of transcription factors,coregulators function as master regulators rather than passive *** a master regulator,MTA3 governs the target selection for Nu RD and functions as a transcriptional ***3dysregulation is associated with tumor progression,invasion,and metastasis in various ***3 is also a key regulator of E-cadherin expression and epithelial-to-mesenchymal *** the functions of MTA3 might help to find additional therapeutic approaches for targeting components of NuRD.