Combined effects of headgroup charge and tail unsaturation of lipids on lateral organization and diffusion of lipids in model biomembranes

作     者：陈晓洁 梁清 

作者机构：Center for Statistical and Theoretical Condensed Matter Physics and Department of PhysicsZhejiang Normal UniversityJinhua 321004China 

出 版 物：《Chinese Physics B》 (中国物理B（英文版）)

年 卷 期：2017年第26卷第4期

页      面：494-501页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 

基　　金：Project supported by the National Natural Science Foundation of China(Grant No.11674287) China Scholarship Council 

主　　题：biomembrane phase separation molecular dynamics simulation coarse grain 

摘      要：Lateral organization and dynamics of lipids in plasma membranes are crucial for several cellular processes such as signal transduction across the membrane and still remain *** this paper,using coarse-grained molecular dynamics simulation,we theoretically study the combined effects of headgroup charge and tail unsaturation of lipids on the lateral organization and diffusion of lipids in ternary lipid *** neutral ternary lipid bilayers composed of saturated lipids,unsaturated lipids,and cholesterols,under the conditions of given temperature and components,the main factor for the phase separation is the unsaturation of unsaturated lipids and the bilayers can be separated into liquid-ordered domains enriched in saturated lipids and cholesterols and liquid-disordered domains enriched in unsaturated *** the headgroup charge is introduced,the electrostatic repulsion between the negatively charged lipid headgroups will increase the distance between the charged *** find that the lateral organization and diffusion of the lipids in the（partially） charged ternary lipid bilayers are determined by the competition between the headgroup charge and the unsaturation of the unsaturated *** the bilayers containing unsaturated lipids with lower unsaturation,the headgroup charge plays a crucial role in the lateral organization and diffusion of *** headgroup charge may make the lipid domains unstable and even can suppress phase separation of the lipids in some ***,in the bilayers containing highly unsaturated lipids,the lateral organization and diffusion of lipids are mainly dominated by the unsaturation of the unsaturated *** work may provide some theoretical insights into understanding the formation of nanosized domains and lateral diffusion of lipids in plasma membranes.