The possible relationship between hepatomegaly and release of HGF into plasma induced by clofibrate in rats
The possible relationship between hepatomegaly and release of HGF into plasma induced by clofibrate in rats作者机构：First Mil Med Univ Inst Pharmaceut Sci Guangzhou 510515 Peoples R China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：1999年第5卷第5期
页 面：440-442页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：解放军医药科研重点项目
主 题：clofibrate hepatocyte growth factors hepatomegaly rat
摘 要：INTRODUCTIONHepatocyte growth factor (HGF) is a newly discovered multifunctional growth factor, and the most potent mitogen known for hepatocyte[1]. It has been shown that recombinant human HGF can protect animal liver against the damaging action of carbon tetrachloride[2]. However, the generation of HGF is also associated with certain liver diseases and several extra-hepatic diseases[3-5]. For example, after partial hepatectomy or carbon tetrachloride poisoning, HGF level in rat plasma increases markedly[3,4]. Therefore, it is believed that HGF plays an important role in the restoration and regeneration of liver after injury.
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