Hepatoprotective effect of Averrhoea carambola fruit extract on carbon tetrachloride induced hepatotoxicity in mice
Hepatoprotective effect of Averrhoea carambola fruit extract on carbon tetrachloride induced hepatotoxicity in mice作者机构：Al Shifa College of PharmacyPoonthavanam P.OKizhatturPerinlhalmannaMalappuram DistKerala.India 679329 Malik Deenar College of PharmacyKasaragodKerala Al Shifa College of PharmacyPoonlhavaimm P.O.KizhatlurPerinthalmannaMalappuram DistKerala.India 679329
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2010年第3卷第8期
页 面：610-613页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
主 题：Averroha carambola Aqueous extract Hepatoprotective activity Carbon tetrachloride
摘 要：Objective:To investigate the hepatoprotective activity of Averroha carambola fruit extract against carbon tetrachloride induced hepatic ***:Hepatotoxicity was induced on albino mice by intraperitoneal administration of CCl4.half an hour after the administration of the last dose of the extract of Averroha carambola *** extract of the fruit of Averroha carambola was administered at a dose of 0.9 g/kg body weight once daily for seven *** hepatic injury and its prevention was assessed by the estimation of serum activities of alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,alkaline phosphates（ALP）,glutathione level and histopathological studies of ***:Pre-treatment of mice with the fruit extract of Averrhoea carambola significantly reduced serum levels of ALT,AST and ALP enzyme and significantly increased the liver reduced glutathione levels 24 h after the administration of carbon tetrachloride.A marked improvement in the enzyme activities and the liver reduced glulathione level was observed in the pre-treated mice 4 days after the administration of carbon tetrachloride. Histopathological studies provided supportive evidence for the biochemical analvsis. Conclusions:The aqueous extract of the fruit of Averrhoea carambola has hepatoprotective effect against carbon tetrachloride induced liver damage in mice.
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