Role of bile acids in the regulation of the metabolic pathways

作     者：Hiroki Taoka Yoko Yokoyama Kohkichi Morimoto Naho Kitamura Tatsuya Tanigaki Yoko Takashina Kazuo Tsubota Mitsuhiro Watanabe 

作者机构：Department of Environmental Information Keio University Fujisawa Kanagawa 252-0882Japan Graduate School of Media and Governance Keio University Fujisawa Kanagawa 252-0882 Japan Division of Endocrinology Metabolism and Nephrology Department of Internal Medicine Keio UniversitySchool of Medicine Shinjuku Tokyo 160-8582 Japan Research Institute of SFC Keio UniversityFujisawa Kanagawa 252-0882 Japan Department of Ophthalmology Keio University School of Medicine Shinjuku Tokyo 160-8582 Japan Department of Environment and Information Studies Keio University Fujisawa Kanagawa 252-0882 Japan Department of Internal Medicine Keio University School of Medicine Shinjuku Tokyo 160-8582 Japan 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2016年第7卷第13期

页      面：260-270页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：Bile acids TGR5/M-BAR Farnesoid X receptor Glucose metabolism Energy metabolism Lipid metabolism Bariatric surgery Microbiota Incretin Bile acid binding resin 

摘      要：Recent studies have revealed that bile acids(BAs)are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological *** major signaling pathways involving the nuclear BAs receptor farnesoid X receptor and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of *** regulate their own homeostasis via signaling *** also affect diverse metabolic pathways including glucose metabolism,lipid metabolism and energy *** paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome.