Pharmacokinetic interaction of Acacia catechu with CYP1A substrate theophylline in rabbits

作     者：Abdullah Mohammed AI-Mohizea Mohammad Raish Abdul Ahad Fahad Ibrahim AI-Jenoobi Mohd Aftab Alam 

作者机构：Department of PharmaceuticsCollege of PharmacyKing Saud University 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2015年第35卷第5期

页      面：588-593页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the Deanship of Scientific Research at King Saud University for funding this research group No. RG-1435-041 

主　　题：Acacia Catechu Cytochromes Herbdrug interactions Pharmacokinetics Theophylline 

摘      要：OBJECTIVE:To investigate the effect of black catechu(BC) on the pharmacokinetics of theophylline(CYP1A2 substrate,with narrow therapeutic index)in ***:In the present investigation the effect of BC on the pharmacokinetics of theophylline,a CYP1A2 substrate was *** the study,BC(264 mg/kg,p.o.) or saline(control group) was given to rabbits for 7 consecutive days and on the 8^(th)day theophylline(16 mg/kg) was administered orally one hour after BC or saline *** samples were withdrawn at different time intervals(0.5,1,1.5,2,3,4,6,8,12,24 and 36 h) from the marginal ear ***:The pretreatment of rabbits with BC resulted in a significant increase in maximum blood concentration,time of peak concentration and area under the concentration time profile curve until last observation which was about 41.32%,35.71%and 15.03%,*** decreases in clearance,volume of distribution,and half-life were *** is suggested that BC pretreatment decreases the CYP1 A metabolic activity leading to increase in bioavailability and decrease in oral clearance of theophylline,which may be due to inhibition of CYP1 ***:BC can significantly alter theophylline pharmacokinetics in vivo possibly due to inhibition of CYP1 A and P-glycoprotein *** on these results,precaution should be exercised when administering BC with CYP1 A substrate.