Compilation and Analysis of Atherosclerosis Gene Expression Data
Compilation and Analysis of Atherosclerosis Gene Expression Data作者机构：Division of Basic Biomedical Sciences Sanford School of Medicine The University of South Dakota Vermillion SD USA
出 版 物：《Advances in Biological Chemistry》 (生物化学进展（英文）)
年 卷 期：2015年第5卷第2期
页 面：142-150页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Atherosclerosis JASPAR TRED rVISTA DNA Microarray Bioinformatics Gene Expression
摘 要：The objective of this project was to search for consensus in differential gene expression data and in regulation of differentially expressed genes among DNA microarray studies of atherosclerotic vessels and plaque. Seventeen DNA microarray studies of atherosclerosis were analyzed. Only 19 genes were found to be differentially expressed in 3 or more of the studies. The nineteen genes belong to classic gene ontologies known to be involved in atherosclerosis: immunity and defense, metabolism, proteases, receptors, and signal transduction. Four bioinformatics programs (TRED, rVISTA, JASPAR, and Ariadne Pathways) were used to further analyze the promoter regions and common upstream regulators of the 19 genes. Twelve of the genes shared nine common upstream regulators, many of them known to affect atherosclerosis, and one possible new pathway was identified that may be involved in this disease.
维普期刊数据库