Amphetamine Conditioned Place Preference in Planarians
Amphetamine Conditioned Place Preference in Planarians作者机构：Center for Substance Abuse Research Temple University School of Medicine Philadelphia USA Department of Pharmaceutical Sciences Temple University School of Pharmacy Philadelphia USA Neuroscience Program Temple University Philadelphia USA
出 版 物：《Journal of Behavioral and Brain Science》 (行为与脑科学期刊（英文）)
年 卷 期：2013年第3卷第1期
页 面：131-136页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Amphetamine Conditioned Place Preference Drug Abuse Planaria
摘 要：Meth- and other amphetamines currently present major drug-abuse concerns. However, the demonstration and study of abuse-related behaviors expressed in animal models is expensive and time-consuming. We previously reported a novel model of conditioned place preference (CPP), which is a standard tool in abuse research, in invertebrates (planarians). In the present study, planarians were tested for light/dark preference, then exposed for 5 min to either d-amphetamine or vehicle (water) in light and then re-tested for place preference (light vs dark). The planarians’ natural strong preference for dark (15 of 16) was significantly altered by amphetamine experience, such that 12 of 16 preferred the unnatural, but amphetamine-associated, light side. These results extend the demonstration of CPP to this invertebrate species and provide further evidence in support of this model to testing/screening amphetamine-like and possibly other drugs of abuse.
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