The Relation between Canine Hip Dysplasia, Genetic Diversity and Inbreeding by Breed

作     者：Frank H. Comhaire 

作者机构：Department of Internal Medicine Ghent University Ghent Belgium 

出 版 物：《Open Journal of Veterinary Medicine》 (兽医学（英文）)

年 卷 期：2014年第4卷第5期

页      面：67-71页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Genetic Diversity Effective Population Size Inbreeding Hip Dysplasia 

摘      要：Objectives: To assess the relation between the prevalence of canine hip dysplasia, inbreeding and genetic diversity by breed. Methods: Retrospective pedigree analysis of 9 breeds based on a reference population of 41,728 individuals, and hip dysplasia assessment in 1745 dogs. Results: Hip dysplasia was less common among breeds with higher coefficient of inbreeding, lower genetic diversity, and highest contribution of one single ancestor to the population. Inbreeding not exceeding 3.25% should be considered safe since it will maintain a sufficiently high genetic diversity within the breed. Clinical Significance: Together with published data on single breeds, the present findings question the general assumption that line-breeding or in-breeding has an adverse effect on the prevalence of hip dysplasia. Hip assessment is indicated in all breeds, but better methods are needed for selecting dogs suitable for reproduction.