Isolation and Characterization of S-Enantiomer in Montelukast

作     者：Vijaya Lakshmi Maddala Kishore Kumar Kakumani Kameswara Rao Chimalakonda Srinivasulu Polisetty P. C. Ray 

作者机构：Inogent Laboratories Pvt Ltd. IDA-Nacharam Hyderabad India Jawaharlal Nehru Technological University Hyderabad India 

出 版 物：《American Journal of Analytical Chemistry》 (美国分析化学（英文）)

年 卷 期：2013年第4卷第1期

页      面：56-61页

学科分类：07[理学] 0703[理学-化学] 

主　　题：(S)-Isomer Montelukast Supercritical Fluid Chromatography (SFC) 

摘      要：A simple and rapid Supercritical Fluid Chromatography (SFC) Method has been developed to isolate and characterize the S-Isomer of Montelukast by using normal phase Amylose based AS-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbon dioxide (CO2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated S-Isomer was characterized by using FT-IR, ESI-MS, HPLC and 1H NMR. The purity of isolated S-Isomer is about 98%.