Isolation and Characterization of S-Enantiomer in Montelukast
Isolation and Characterization of S-Enantiomer in Montelukast作者机构:Inogent Laboratories Pvt Ltd. IDA-Nacharam Hyderabad India Jawaharlal Nehru Technological University Hyderabad India
出 版 物:《American Journal of Analytical Chemistry》 (美国分析化学(英文))
年 卷 期:2013年第4卷第1期
页 面:56-61页
主 题:(S)-Isomer Montelukast Supercritical Fluid Chromatography (SFC)
摘 要:A simple and rapid Supercritical Fluid Chromatography (SFC) Method has been developed to isolate and characterize the S-Isomer of Montelukast by using normal phase Amylose based AS-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbon dioxide (CO2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated S-Isomer was characterized by using FT-IR, ESI-MS, HPLC and 1H NMR. The purity of isolated S-Isomer is about 98%.