CD38 expression on CD8+ cells—Its influence on development of tuberculosis in HIV positive individuals
CD38 expression on CD8+ cells—Its influence on development of tuberculosis in HIV positive individuals作者机构：1Immunology and Molecular Biology Division LEPRA India-Blue Peter Public Health & Research Centre Hyderabad India Department of Genetics Osmania University Hyderabad India Immunology and Molecular Biology Division LEPRA India-Blue Peter Public Health & Research Centre Hyderabad India
出 版 物：《Open Journal of Immunology》 (免疫学期刊（英文）)
年 卷 期：2012年第2卷第2期
页 面：65-71页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：HIV-TB CD38 CD8 CD4 Viral Load
摘 要：CD38 expression on CD8+ cells seems to correlate well with HIV viral-loads, while the ex-pression levels are thought to be low in patients with tuberculosis. This study aimed at determining the levels of CD38 expression in HIV+ individuals who develop tuberculosis. Expression levels of CD8 and CD38 were analysed in peripheral blood collected from HIV (73), TB (32), HIV-TB (31) and healthy controls (20). The percentage of CD8+/CD38+ cells significantly increased during the first few years of seropositivity and decreased during 5 - 6 years. A decline in the expression of CD38, especially on CD8+ cells in a HIV+ individual within first 2 years of seropositivity, may be indicative of susceptibility to tuberculosis. This observation was reiterated when two patients developed TB during follow-up. CD38 on CD8 cells could perhaps be useful as an early biomarker for tuberculosis in HIV-positive individuals.
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