Midtrimester pregnancy loss and cervical incompetence—Is there an association with connective tissue laxity?
Midtrimester pregnancy loss and cervical incompetence—Is there an association with connective tissue laxity?作者机构：Genetic Services Victoria Royal Children’s Hospital Melbourne Australia University of Melbourne Parkville Australia
出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)
年 卷 期：2014年第4卷第1期
页 面：28-32页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Cervical Incompetence Connective Tissue Laxity Ehlers Danlos Syndrome Pregnancy Complications Beighton Score
摘 要：Objectives: The basic mechanisms of cervical incompetence remain unknown although preliminary histological, biochemical and DNA studies suggest connective tissue pathology may be a contributing factor. Certain connective tissue disorders are known to be associated with obstetric complications. Utilising a standardised established scoring system for connective tissue laxity, this study aimed to test the relationship between clinical evidence of connective tissue laxity and cervical incompetence. Methods: This case-control study involved pregnant and non-pregnant women with a history of mid-trimester pregnancy loss in the absence of major bleeding, infection and uterine abnormalities and a control group of women with uncomplicated obstetric histories. Relevant medical details were obtained. Connective tissue laxity was assessed utilizing the Beighton scoring system. Potential confounding factors, including age, pregnancy and gestation were explored. Results: The frequency of connective tissue laxity between the cases [n = 29] was not statistically different from the controls [n = 58] [p = 0.391] suggesting a lack of association between cervical incompetence and clinical evidence of connective tissue laxity. Conclusion: Although no clear evidence of connective tissue laxity was demonstrated, it is possible that cervical incompetence is associated with abnormal connective tissue. But this abnormality is different from the defect that underlies joint hypermobility and skin elasticity.
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