Facile Synthesis of Novel Chiral Bicyclic Thioureas and Their Crystal Structures

作     者：Ping An Wang Hui Fang Nie Lin Jie Yan Sheng Yong Zhang 

作者机构：Department of Medicinal Chemistry School of Pharmacy Fourth Military Medical University Xi’an China 

出 版 物：《International Journal of Organic Chemistry》 (有机化学国际期刊（英文）)

年 卷 期：2012年第2卷第1期

页      面：15-20页

学科分类：07[理学] 0703[理学-化学] 

主　　题：Chiral Bicyclic Thiourea cis-2 5-Disubstituted Pyrrolidine X-Ray Analysis 

摘      要：The novel well-defined chiral bicyclic thioureas based on enantiopure unsymmetric cis-2,5-disustituted pyrrolidine skeleton were firstly synthesized and fully characterized by their 1H NMR, 13C NMR and HRMS. Their absolute configurations were also determined by single-crystal X-ray analysis.