Dual role for the unfolded protein response in the ovary： adaption and apoptosis
Dual role for the unfolded protein response in the ovary： adaption and apoptosis作者机构：Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction Ministry of Education Center of Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China
出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)
年 卷 期：2017年第8卷第1期
页 面：14-24页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 071009[理学-细胞生物学] 0703[理学-化学] 0836[工学-生物工程] 071002[理学-动物学]
基 金：This work was supported in part by the National Basic Research Program （973 Program） （No. 2014CB943203） ＂Reproductive health and major birth defects prevention and control research＂ Key Special Fund （No. 2016YFC1000601） the National Natural Science Foundation of China （Grant Nos.31371521 and 81571400） Beijing Nova Program （xxjh2015011） and Special Projects for Cultivation and Development of Science and Technology Innovation Base （No. Z151100001615023）.
主 题：endoplasmic reticulum stress obesity,ovary follicle ovarian diseases
摘 要：The endoplasmic reticulum （ER） is the principal organelle responsible for several specific cellular functions including synthesis and folding of secretory or membrane proteins, lipid metabolism, and Ca^2＋ storage. Different physiological as well as pathological stress conditions can, however, perturb ER homeostasis, giving rise to an accumulation of unfolded or misfolded proteins in the ER lumen, a condition termed ER stress. To deal with an increased folding demand, cells activate the unfolded protein response （UPR）, which is initially protective but can become detrimental if ER stress is severe and prolonged. Accumulating evidence demonstrates a link between the UPR and ovarian development and function, including follicular growth and maturation, follicular atresia, and corpus luteum biogenesis. Additionally, ER stress and the UPR may also play an important role in the ovary under pathological conditions. Understanding the molecular mechanisms related to the dual role of unfolded protein response in the ovarian physiology and pathology may reveal the pathogenesis of some reproductive endocrine diseases and provide a new guidance to improve the assisted reproductive technology. Here we review the current literature and discuss concepts and progress in understanding the UPR, and we also analyze the role of ER stress and the UPR in the ovary.
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