Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering

作     者：Shiying Li Tianmei Qian Xinghui Wang Jie Liu Xiaosong Gu 

作者机构：Key Laboratory of Neuroregeneration of fiangsu and the Ministry of Education Co-lnnovation Center of Neuroregeneration Nantong University Nantong fiangsu 226001 China 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2017年第3卷第1期

页      面：3-15页

核心收录：

学科分类：0810[工学-信息与通信工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 0808[工学-电气工程] 07[理学] 0817[工学-化学工程与技术] 0807[工学-动力工程及工程热物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：This work was supported by the National Basic Research Program of China （973 Program  2014CB542202）  the National HiTech Research and Development Program of China （863 Program  2012AA020502）  the National Natural Science Foundation of China （81130080 and 31300879）  and the Key University Science Research Project of Jiangsu Province （16KJA310005）. It was also a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）. 

主　　题：组织工程 非编码RNA(ncRNA) microRNA(miRNA) 神经 皮肤 肝脏 血管系统 肌肉 

摘      要：Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth research on the regulation and delivery of ncRNAs may improve their application in tissue engineering.The aim of this review is: to outline essential ncRNAs that are related to tissue engineering for the repair and regeneration of nerve, skin, liver, vascular system, and muscle tissue; to discuss their regulation and delivery; and to anticipate their potential therapeutic applications.