Synthesis,Characterization,Nematocidal Activity and Docking Study of Novel Pyrazole-4-carboxamide Derivatives

作     者：赵文 沈钟华 邢家华 许天明 彭伟立 刘幸海 

作者机构：College of Chemical Engineering Zhejiang University of Technology Zhejiang Base of National Southern Pesticide Research Centre Zhejiang Research Institute of Chemical Industry 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2017年第36卷第3期

页      面：423-428页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 070303[理学-有机化学] 0904[农学-植物保护] 0703[理学-化学] 

基　　金：supported by Zhejiang Provincial Science Foundation of China(No.LY16C140007) 

主　　题：trifluoromethylpyrazole nematocidal activity synthesis docking 

摘      要：A series of novel 1-methyl-3-（trifluoromethyl）-^1H-pyrazole-4-carboxamide derivatives were designed based on our previous work and synthesized. All these title compounds were confirmed by NMR and MS. The primarily nematocidal activity results indicated that some of them exhibited good control efficacy against the tomato root-knot nematode disease caused by M. incognita. The docking results indicated that compound 6n interacts with amino acid residue Trp 279 of Ach E via hydrogen bond and amino acid residue Trp 84 of Ach E via π-π interaction.