Polyhydric Corrole and Its Gallium Complex： Synthesis, DNA-binding Properties and Photodynamic Activities
Polyhydric Corrole and Its Gallium Complex： Synthesis, DNA-binding Properties and Photodynamic Activities作者机构：School of Chemistry and Chemical Engineering Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology Guangzhou Guangdong 510641 China School of Pharmacy Guangdong Pharmaceutical University Guangzhou Guangdong 510006 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2016年第34卷第10期
页 面：997-1005页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学]
基 金：This work was supported by the following institutions: the National Natural Science Foundation of China (NNSFC Nos. 21371059 21376099) the High-Level Personnel Project of Guangdong Province in 2013 and the Joint Natural Science Fund of the Department of Science and Technology and the First Affiliated Hospital of Guangdong Pharmaceutical University (No. GYFYLH201315) the National Science Foundation of Guangdong Province (No. 2016A030313728)
主 题：corroles gallium DNA binding photosensitizers anticancer
摘 要：A new hydrophilic polyhydric corrole （1） and its Ga（III） complex （1-Ga） were synthesized and characterized. Corroles 1 and 1-Ga bind to calf thymus DNA externally and exhibit remarkable photonuclease-like activity. Singlet oxygen （102） was identified as the reactive oxygen species involved. These corroles also exhibit significant photocytotoxicity against HeLa, A549, BEL-7402 and HepG2 tumor cell lines. They mainly accumulated in the nuclei of tumor cells. ROS-mediated mitochondrial damage and intracellular DNA disintegration contributed to the observed photodynamic activity.
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