Efficient derivation of embryonic stem cells from NOD-scid 112rg mice

作     者：Kang Liu (1) (2) Riguo Fang (1) (2) Haibo Li (1) Weifeng Yang (4) Zhenchuan Miao (4) Jinhua Wen (1) Hongkui Deng (1) (2) (3) 

作者机构：1.Peking University Stem Cell Research Center Department of Cell Biology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China 2.The MOE Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University Beijing 100871 China 4.VITALSTAR Bitechnology Co. Ltd Beijing China 3.Shenzhen Stem Cell Engineering Laboratory Key Laboratory of Chemical Genomics Peking University Shenzhen Graduate School Shenzhen 518055 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2015年第6卷第12期

页      面：916-918页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 071002[理学-动物学] 

基　　金：supported in part by the Postdoctoral Fellowship of Peking-Tsinghua Center for Life Sciences 国家自然科学基金 国家973计划 supported by the National Science and Technology Major Project 

主　　题：derivation stem mice 

摘      要：For decades, the stem cell field has pursued the development of humanized mice to further enhance our understanding of human hematopoiesis, innate immunity, infectious diseases, cancer biology and regenerative medicine. One significant breakthrough in generating humanized mice was the development of NOD-scid 112rg mice, which are double homozygous for the severe combined immun- odeficiency （SCID） mutation and interleukin-2Rg （11-2Rg） allelic mutation （gamma c null） （Ito et al., 2002）.