Study on insulin erythrocyte receptors inpatients w ith m yocadial infarction

作     者：Pan Qixing1, Liu Huajun2, Zhu Qing1(1 Departm ent of Cardiology, Affiliated Hospital, Shandong Medical University, Jinan 250012 2 Zhong Shan Hospital, Shanghai Medical University, Shanghai 

作者机构：山东医科大学附属医院 山东 上海医科大学附属中山医院 上海 

出 版 物：《吉林大学学报(医学版)》 (Journal of Jilin University(Medicine Edition))

年 卷 期：1999年第25卷第4期

页      面：489-492页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Study on insulin erythrocyte receptors inpatients w ith m yocadial infarction 

摘      要：It has been hypothesized that the defects of insulin receptors may play an important role in the insulin resistance of coronary heart disease. As a test of this hypothesis, 20 male patients with myocardial infarction, 20 male patients with type 2 diabetes mellitus and 20 normal subjects as control were *** insulin were determined; at the meantinme, insulin receptors of erythrocyte were indentified by means of 125 I -labeled insulin binding to erythrocytes while the affinity constants (K1 ,K2) and the number of receptors with different affinity and capacity (Q1,Q2) were calculated according to Scatchard＇s graphic method. The results showed that the number of insulin receptors with low affinity (Q2) on erythrocytes,K1, K, were lower in patients with myocardial infarction than those in controls ; and Q2, K1 in patents with type 2 diabetes mellitus were also lower. So we concluded that the mechanism of insulin resistance in coronary heart disease might be associated with insulin receptor and affinity abnormalities ,differed from that in diabetic state with some degree of post-receptor defects, which suggests that there may be an interrelationship among insulin receptor defects, insulin resistance,hyperinsulinemia in developing coronary heart disease.