The PilZ domain of MrkH represents a nove ）NA binding motif

作     者：Feng Wang Qing He Kaixuan Su Fei Gao Yan Huang Zong Lin Deyu Zhu Lichuan Gu 

作者机构：State Key Laboratory of Microbial Technology Shandong University Jinan 250100 China Department of Biotechnology and Biomedicine Yangtze Delta Region Institute of Tsinghua University Jiaxing 314006 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2016年第7卷第10期

页      面：766-772页

核心收录：

学科分类：0710[理学-生物学] 0711[理学-系统科学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 081104[工学-模式识别与智能系统] 08[工学] 0817[工学-化学工程与技术] 0811[工学-控制科学与工程] 071102[理学-系统分析与集成] 081103[工学-系统工程] 

基　　金：国家自然科学基金 The Shandong Provincial Funds for Distinguished Young Scientists Grant supported by Shandong Province Natural Science Foundation Grant 国家自然科学基金 

摘      要：MrkH is the first characterized c-di-GMP related transcrip- tional regulator which affects type 3 fimbrial expression in response to cellular c-di-GMP level, and thus plays an important role in the biofilm formation of Klebsiella pneu- moniae （Murphy and Clegg, 2012; Wilksch et al., 2011）. However, how MrkH recognizes c-di-GMP and the target DNA sequence remains obscure.