Intestinal acyl-CoA synthetase 5: Activation of long chain fatty acids and behind
Intestinal acyl-CoA synthetase 5: Activation of long chain fatty acids and behind作者机构：Institute of PathologyRWTH Aachen University52074 AachenGermany
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2013年第19卷第42期
页 面：7369-7373页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Acyl-CoA synthetase Apoptosis Carcinogenesis Colorectal cancer Intestinal homeostasis
摘 要：The intestinal mucosa is characterized by a high complexity in terms of structure and functions and allows for a controlled demarcation towards the gut *** the one hand it is responsible for pulping and selective absorption of alimentary substances ensuring the immunological tolerance,on the other hand it prevents the penetration of micro-organisms as well as bacterial *** continuous regeneration of surface epithelia along the crypt-villus-axis in the small intestine is crucial to assuring these various *** core phenomena of intestinal epithelia regeneration comprise cell proliferation,migration,differentiation,and *** partly contrarily oriented processes are molecularly balanced through numerous interacting signaling pathways like Wnt/β-catenin,Notch and Hedgehog,and regulated by various modifying *** of these modifiers is acyl-CoA synthetase 5(ACSL5).It plays a key role in de novo lipid synthesis,fatty acid degradation and membrane modifications,and regulates several intestinal processes,primarily through different variants of protein lipidation,e.g.,***5 was shown to interact with proapoptotic molecules,and besides seems to inhibit proliferation along the *** of its proapoptotic and antiproliferative characteristics it could be of significant relevance for intestinal homeostasis,cellular disorder and tumor development.
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