Tumor localization of anti-gastric cancer monoclonal antibody MGb_2-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901

作     者：陈敏 黎松 邓敬兰 张学庸 陈希陶 

作者机构：Department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'an 710032 Laboratory of GastroenterologyXijing HospitalFourth Military Medical UniversityXi'an 710032 

出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)

年 卷 期：1992年第7卷第1期

页      面：81-83页

学科分类：10[医学] 

主　　题：stomach neoplasms antibodies monoclonal deunomycin antibody-toxin conjugates iodine radioisotops mice nude 

摘      要：In the present study,an anti-gastric cancer monoclonal antibody MGb2-daunomycin（DM）conjugate was prepared by cis-aconitic anhydride *** distribution of the conjugatein nude mice bearing human gastric carcinoma SGC-7901 was *** to five moleculesof DM were introduced into each molecule of antibody while the antigen-binding capacity ofthe antibody was *** conjugate could be satisfactorily localized in the ***-six hours after intraperitoneal injection of 125I-MGb2-DM conjugate,the ratio ofradioactivity per milligram of tumor to that per milligram of blood reached 203,the result beingquite similar to that of unmodified MGb2.