MUTUAL POTENTIATION OF THE ANA-LGSIC EFFECT OF MORPHINE MET-ENKE-PHALIN AND DYNORPHIN AND THEIR ANTAGONISM BY NALOXONE

作     者：Wang Junfeng Ren Minfeng Han Jisheng Department of Physiology Beijing Nedical University Institute of Acupuncture Science, An Hui college of Traditional Chinese Medical Institute of Basic Medical Sciences, Chinese Academy of Medical Science 

出 版 物：《针刺研究》 (Acupuncture Research)

年 卷 期：1989年第Z1期

页      面：150-151页

核心收录：

主　　题：NX NS MUTUAL POTENTIATION OF THE ANA-LGSIC EFFECT OF MORPHINE MET-ENKE-PHALIN AND DYNORPHIN AND THEIR ANTAGONISM BY NALOXONE ANA TFL 

摘      要：The present study deals primarily with the antagonistic effect of Naloxone(NX) against mutual potentiation of morphine (Mor), mek-enkephalin (MEK)and dyno phin (Dyn) in their analgesic effects. (1) The rats were divided into 4 groups, ie. NS, NX 0. 02, 0. 1 and 0. 5mg/kggroups. A mixture of Dyn 2. 5noml and Mot 7. 5noml was injected in thebeginning via intrathecal cannulae into each rat. Percentage incrcase in TFLin all 4 groups was between 94±19% and 109±20% 10rain later. After thateach grcup was injected subcutaneously NS, NX 0.02, 0.1 and 0.5mg/kg respe-ctively and was observed continuously for 50min. The results suggest that the