EFFECTS OF ANISODINE ON MEMORY

作     者：匡培根 戴富林 张凤英 匡培梓 陈双双 

作者机构：Neurotransmitter Research Laboratory Chinese PLA General Hospital Academia Sinica Institute of Psychology 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志(英文版))

年 卷 期：1982年第2卷第4期

页      面：277-284页

主　　题：CAT EFFECTS OF ANISODINE ON MEMORY ACh 

摘      要：Anisodine(AT3)is a new alkaloid isolatedfrom Scopolia tangutica,Anisodus tanguticus,a plant of Solauaeeae family,collected ***3has anticholinergic *** influences of AT3on memory behavior,hip-pocampal electrical activity and acetylcholinecontent in animals were *** evalua-tion of memory deficits was based on the fol-lowing:(1)percentage of conditioned passiveavoidance reaction(CAR),(2)mean responsetime,(3)mean ability to perform correctly 5successive times in 10 trials,(4)mean numberof trials to correctly perform 9 out of 10 *** was found that AT3influences unconsolidatedmemory(three day training period)more thanconsolided memory(six day training period).It was also observed that the nmemonia effectsof AT3was associated with ECoG changes andcholinergic reduction in *** majorfindings arising from studies of hippocampalelectrical activity in orienting experiments isthat hippocampal electrical response decreasedafter *** findings suggestedthat the chronic administration of AT3raises thepossibility of impairing the ability of patients,particularly elderly ones,to learn new materialand to store,or acquire new information intolong-term memory.