STUDIES ON THE TRANSMISSION OF HUMAN HEPATITIS A VIRUS TO STUMP-TAILED MONKEY

作     者：毛江森 郭杏英 黄海鹰 余佩华 黄柏章 陈念良 郁俊豪 谢汝英 MAO JIANGSEN;GUO XINGYING;HUANG HAIYING;YU PEIHUA;HUANG BOZHANG;DING ZHANGHU;CHEN NIANLIANG;YU JUNHAO AND XIE RUYING Department of Virology, Zhejiang Institute of Experimental Medicine & Hygiene

作者机构：Department of Virology Zhejiang Institute of Experimental Medicine & Hygiene 

出 版 物：《Science in China,Ser.A》 (中国科学A辑(英文版))

年 卷 期：1981年第11期

页      面：1590-1596页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：HAV STUDIES ON THE TRANSMISSION OF HUMAN HEPATITIS A VIRUS TO STUMP-TAILED MONKEY SGPT 

摘      要：The newly-caught stump-tailed monkeys （Macaca speciosa） with negative antibody to hepa-titis A were inoculated with Luman hepatitis A *** following findings were observedin the monkeys after inoculation: （i） the elevation of activities of the serum glutamic-pyruvictransaminase, lactate dehydrogenase and its isoenzyme（LDH5）, （ii） the seroconversion ofantibody to hepatitis A virus,（iii） the shedding of hepatitis A antigen in feces. These findingsshow that the stump-tailed monkey （Macaca speciosa） is susceptible to infection of humanhepatitis A virus. The virus recovered from the feces of the infected monkey, named as Hang-zhou A-1A strain of hepatitis A virus, has experienced two generations of successful trans-mission in monkeys.