In vivo bone dynamic imaging of PTH's anabolic effect

作     者：Allison R.Altman Chantal de Bakker Wei-Ju Tseng Beom Kang Huh Abhishek Chandra Ling Qin X.Sherry Liu 

作者机构：McKay Orthopaedic Research LaboratoryDepartment of Orthopaedic SurgeryPereman School of MedicineUniversity of Pennsylvania 

出 版 物：《医用生物力学》 (Journal of Medical Biomechanics)

年 卷 期：2013年第28卷第S1期

页      面：47-50页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by McCabe pilot award and the Penn Center for Musculoskeletal Disorders(NIH/NIAMS P30AR050950) 

主　　题：osteoporosis remodeling trabecular skeletal deterioration impaired inhibit stabilize approved histology 

摘      要：Introduction Aging shifts bone remodeling toward a negative balance between bone formation and resorption,causing bone loss and increased fracture ***-resorptive agents are commonly used to inhibit bone resorption and stabilize bone *** they are effective to prevent further bone loss,there is also a great need for anabolic agents which can reverse bone deterioration and regain lost skeletal ***,the only FDA-approved anabolic treatment for osteoporosis,greatly stimulates bone *** therapy of anti-resorptive treatments,such as alendronate(ALN),and PTH have been proposed and are expected to further increase bone ***,studies show conflicting results regarding the effectiveness