An investigation of the effects of dust storms on rat lung using HRCT and blood gas analysis

作     者：FengFeng Lei WanYin Luo ZhiBao Dong YingZhu Sang LiZhu Luo Gang Huang Hua Liu QiZhang Chen 

作者机构：Department of Respiration the People's Hospital of Gansu Province Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Department of Radiation Imaging the People's Hospital of Gansu Province 

出 版 物：《Research in Cold and Arid Regions》 (寒旱区科学（英文版）)

年 卷 期：2016年第8卷第4期

页      面：319-324页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 070601[理学-气象学] 0706[理学-大气科学] 100402[医学-劳动卫生与环境卫生学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (41161019  41461020) 

主　　题：dust storm lung blood gas analysis HRCT wind tunnel simulation 

摘      要：The increasing intensity and frequency of sand-dust storms in China has led to greater prominence of associated environmentaland health issues. Many studies have focused on the health effects of air particulate contaminants, but fewformal investigations have studied the effects of sand-dust storms on human and animal health. The aim of this study wasto investigate the effects of dust storms on rat lung by using high resolution computed tomography （HRCT） and blood gasanalysis through a wind tunnel simulating. We found that the rat lung damage effects can be detected by the HRCT imagingafter exposure to sand-dust storm environments, but had no obvious result through blood gas analysis. Exposure durationspositively correlated with the damage degree to lung tissue. These will provide some evidence for clinical diagnosis ofnon-occupational pneumoconiosis.