Risk factors for adverse reactions of fundus fluorescein angiography

作     者：Yi Yang Jingzhuang Mai Jun Wang 

作者机构：Department of Qphthalmology Epidemiology DivisionDepartment of Cardiac SurgeryGuangdong Cardiovascular InstituteGuangdong General HospitalGuangzhou 510080China 

出 版 物：《Eye Science》 (眼科学报（英文版）)

年 卷 期：2016年第31卷第2期

页      面：86-91页

学科分类：1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

主　　题：不良反应 血管造影 荧光素 危险因素 过敏性疾病 眼底 心脑血管疾病 肾脏疾病 

摘      要：Background:To explore the difference between the outcomes of correlations between a series of variables and adverse reactions(ARs)to fluorescein from univariate and multivariate analysis and to evaluate the nausea effects in different age ***:A retrospective study of patients undergoing consecutive fluorescein angiography between March2010 and February 2012 was *** patients were excluded on the ground of age,presence of atopy,allergy history,previous procedures without severe allergic ARs,asymptomatic hypertension and kidney failure with serum creatinine levels lower than 250μmol/L or with renal ***:A total of 829 patients were enrolled and 22.2%of them had *** majority of reactions were nausea(12.1%)which occurred less when age became old(P0.0001).When the correlations between a series of variables and ARs were assessed separately,age(P0.0001),prior reactions(P0.0001)and motion sickness(P=0.0062)were highly and cardio/cerebrovascular disease(P=0.0015),diabetes(P=0.0001)and renal disease(P=0.0219)were lowly related to ***,when the correlations were assessed simultaneously,only age[odd ratio(OR)0.974;95%confidence interval(CI),0.962–0.986],prior reactions(OR 5.596;95%CI,2.083–15.029)and motion sickness(OR 4.849;95%CI,1.583–14.856)were statistically correlated with ***:Fluorescein angiography is a safe procedure for patients who are relatively healthy but with a history of any systemic *** age,prior reactions and motion sickness which are highly related to emetic events should be considered in the evaluation of ARs to fluorescein.