A full-length 3D structure for MAPK/ERK kinase 2 (MEK2)

作     者：LIANG Hao LIU Tao CHEN FangJin LIU ZhaoQing LIU ShaoJun 

作者机构：State Key Laboratory of Proteomics Department of Neurobiology Institute of Basic Medical Sciences Beijing 100850 China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2011年第54卷第4期

页      面：336-341页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the National Natural Science Foundation of China(Grant No.30670791) the National Basic Research Program of China(Grant No.2009CB918301) the National High Technology Research and Development Program of China(Grant No.2008AA02Z124) the State Key Laboratory of Proteomics(Grant No.SKLP-Y200810) 

主　　题：MEK2 homology modeling molecular dynamics simulation 3D structure 

摘      要：As a pivotal signal pathway,the Ras/Raf/MEK/ERK cascade can be activated by multiple extracellular stimuli and can transmit signals to diverse *** remains to be elucidated how so many different signals can be variously transferred by only two MEK molecules(MEK1 and MEK2) .Because of technological limitations the complete structures of the MEKs are still ***,we report the full-length structure of MEK2 obtained by homology modeling and molecular dynamics *** simulations show that the N-terminal part of MEK2 is highly flexible and this flexibility may enable MEK2 to interact with ERKs and other ligands in diverse manners that correspond to various upstream signals and downstream consequences.