Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues

作     者：Jing Shan SHEN Li Jun LEI Hai Fang MAO Jian Feng LI Ru Yun JI 

作者机构：Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 200031 Shanghai Jahwa Fine Chemicals Co.LtdShanghai 200040 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2001年第12卷第11期

页      面：951-954页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：5-substituted hexahydro-1H-1,4-diazepine analogues synthesis bioactivity 

摘      要：5-Substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N,N -dibenzyl-1, 2-ethylenediamine and methyl 2, 4-dibromide butyrate through nucleophilic substitution, reduction, chlorination, debenzylation and amidation. Bioactivity tests showed that 9a had the highest agonist activity.