Local Compression Properties of Double-Stranded DNA Based on a Dynamic Simulation

作     者：LEI Xiao-Ling QI Wen-Peng FANG Hai-Ping 雷晓玲;亓文鹏;方海平

作者机构：Division of Interfacial WaterShanghai Institute of Applied PhysicsChinese Academy of SciencesP.O.Box 800-204Shanghai 201800 

出 版 物：《Chinese Physics Letters》 (中国物理快报（英文版）)

年 卷 期：2013年第30卷第12期

页      面：186-190页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：Supported by the National Natural Science Foundation of China under Grant Nos 11305237 and 11174310 China Post-doctoral Science Foundation Project under Grant No 2012M511159 Shanghai Supercomputer Center,and Supercomputing Center of Chinese Academy of Sciences 

主　　题：winding base process 

摘      要：Using a simple sphere-tip compression system,the local radial mechanical properties of DNA are systematically studied by changing the tip *** the tip size decreases,the radial compression elastic properties under external loads become sensitive to the tip size and the local DNA conformation.A sudden force break appears in the compression-force curve when the tip size is less than or equal to 12 nm in *** analysis of the hydrogen bonds and the base stacking interaction shows that a local unwinding process *** the compression process,firstly the hydrogen bonds between complement base pairs are *** the compression accumulating,the local backbones in the compression center are unwound from the double helix conformation to a kind of parallel *** local unwinding behavior deduced by external loads is helpful to understand the biological process and is important to DNA-based nanomechanical devices.